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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1986-6-25
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pubmed:abstractText |
The reduction in hookworm egg counts was determined in children treated with 1 and 2 doses of metrifonate. Kenyan primary school children were allocated to receive either 10.0 mg (n = 53) or 7.5 mg (n = 53) of metrifonate per kg of body weight (mg/kg) or a placebo (n = 26). Two doses of 10.0 mg/kg reduced hookworm egg counts (from arithmetic means of 4,177 to 438 eggs per gram of feces [epg]) more than did 2 doses of 7.5 mg/kg (from 4,329 to 1,392 epg; P less than 0.01). Two doses of metrifonate reduced egg counts more than did 1 dose (P less than 0.0001). The placebo group did not show a significant change in egg counts. The single dose of 10.0 mg/kg led to a 78% reduction in hookworm egg counts (from 4,177 to 918 epg), a level unlikely to cause iron deficiency anemia. This was as effective as 2 doses of 7.5 mg/kg, and was more easily administered than 2 or 3 doses. The further reduction after a second dose of 10.0 mg/kg (to 438 epg) is probably not of practical importance. This study shows that metrifonate, even in a single dose for treatment of S. haematobium, is also useful in reducing hookworm egg counts.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0002-9637
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3706623-Ancylostomatoidea,
pubmed-meshheading:3706623-Child,
pubmed-meshheading:3706623-Feces,
pubmed-meshheading:3706623-Female,
pubmed-meshheading:3706623-Hookworm Infections,
pubmed-meshheading:3706623-Humans,
pubmed-meshheading:3706623-Kenya,
pubmed-meshheading:3706623-Male,
pubmed-meshheading:3706623-Parasite Egg Count,
pubmed-meshheading:3706623-Trichlorfon
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pubmed:year |
1986
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pubmed:articleTitle |
The effectiveness of metrifonate in reducing hookworm infection in Kenyan school children.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|