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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1986-6-18
|
| pubmed:abstractText |
The renal catabolism of 125I-glicentin has been studied in vivo by the disappearance of this peptide from the plasma of bilaterally nephrectomized, ureteral-ligated, or normal rats and by using tubular microinfusion techniques. In addition the catabolism of glicentin by the isolated, perfused kidney has been studied. Results from in vivo studies demonstrated that half-disappearance time was lower in control (59.5 +/- 1.8 min) than in bilaterally nephrectomized rats (97.2 +/- 2.6 min), and this value was significantly higher than that of ureteral-ligated animals (83.2 +/- 1.1 min, P less than 0.005). Microinfusion experiments revealed that when 125I-glicentin was injected into the proximal tubule, no trichloroacetic-precipitable radioactivity was recovered in the urine, whereas most of inulin injected was recovered. By contrast most of the 125I-glicentin injected into the distal tubule was recovered in the urine. In isolated kidney experiments, organ clearance rate of 125I-glicentin averaged 0.88 +/- 0.10 ml/min, a value significantly higher than that of glomerular filtration rate (0.72 +/- 0.06 ml/min, P less than 0.005, paired data), and both parameters showed a close linear relationship (r = 0.90). Urinary clearance of glicentin was negligible. These results demonstrate that the kidney plays a major role in the catabolism of glicentin, mainly by glomerular filtration and tubular catabolism. The site of tubular catabolism appears to be the proximal tubule. Peritubular uptake was minimal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
250
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E545-50
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:3706521-Animals,
pubmed-meshheading:3706521-Chemical Precipitation,
pubmed-meshheading:3706521-Chromatography, Gel,
pubmed-meshheading:3706521-Glomerular Filtration Rate,
pubmed-meshheading:3706521-Glucagon,
pubmed-meshheading:3706521-Iodine Radioisotopes,
pubmed-meshheading:3706521-Kidney,
pubmed-meshheading:3706521-Kidney Tubules, Distal,
pubmed-meshheading:3706521-Kidney Tubules, Proximal,
pubmed-meshheading:3706521-Kinetics,
pubmed-meshheading:3706521-Ligation,
pubmed-meshheading:3706521-Metabolic Clearance Rate,
pubmed-meshheading:3706521-Nephrectomy,
pubmed-meshheading:3706521-Perfusion,
pubmed-meshheading:3706521-Proglucagon,
pubmed-meshheading:3706521-Protein Precursors,
pubmed-meshheading:3706521-Rats,
pubmed-meshheading:3706521-Rats, Inbred Strains,
pubmed-meshheading:3706521-Ureter
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Renal catabolism of 125I-glicentin.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|