Linked Life Data

3703896

Source:http://linkedlifedata.com/resource/pubmed/id/3703896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-6-17
pubmed:abstractText
The effects of chronic treatment with phenylpropanolamine (PPA) on body weight (BW), food intake (FI), and water intake (WI) and interscapular brown adipose tissue (IBAT) thermogenesis in adult male Sprague-Dawley rats were evaluated in 2 experiments. In Experiment 1, rats were treated (IP) twice daily (0900 and 2100 hr) for 12 days with either saline or 5, 10, or 20 mg/kg dl-PPA. Rats treated with 20 mg/kg dl-PPA exhibited significant decreases in both FI and BW but not WI. Basal IBAT temperature was slightly increased in chronic 20 mg/kg dl-PPA rats and there was no evidence of tolerance to the acute IBAT thermogenic effect of 20 mg/kg dl-PPA. In Experiment 2, rats were treated twice daily (0900 and 2100 hr) for 12 days with either saline or 20 mg/kg of either d-PPA or l-PPA. There was a 2-fold difference in the potency of these PPA isomers on FI, BW and IBAT thermogenesis. Body composition analyses revealed that l-PPA, but not d-PPA, induced a significant loss of carcass lipid without significant changes in carcass ash, water or protein levels. These data suggest that the weight-reducing action of PPA may reflect a combined effect of this drug on both food intake and BAT thermogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Weight loss induced by chronic phenylpropanolamine: anorexia and brown adipose tissue thermogenesis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't