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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1986-6-11
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pubmed:abstractText |
In order to elucidate the morphological correlates of bladder-rectal dysfunctions in Shy-Drager syndrome, the sacral spinal cord was cytoarchitectonically studied and 3 groups of sacral motor neurons, the posterolateral motor neuron column (PL), inferior intermediolateral nucleus (IML) and cell group X of Onuf (Onuf), were morphometrically quantitated at the S3 level (5 cases), after which the results were compared with those from amyotrophic lateral sclerosis (5 cases) and an age-matched control group (4 cases). The sacral autonomic preganglionic nucleus of IML was localized chiefly in the S3-4 segments and was maximally developed in the caudal one-third of S3. The cell group X of Onuf was localized between the middle of S2 and the rostral one-third of S3 as a longitudinal slender column in the ventral horn. Between these two nuclei at the rostral S3 level, a connecting cellular bridge of neurons of intermediolateral cell type was identified. Morphometry disclosed a marked deprivation of IML, Onuf and somatic motor neurons in Shy-Drager syndrome and a severe loss of somatic motor neurons and a modest deprivation of IML neurons in ALS. These results imply that these two disorders distinguished by different clinical manifestations share a common loss of somatic motor and parasympathetic motor neurons at least in the sacral cord. There are, however, certain gradients in the severity of involvement in these heterogeneous cell groups.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-510X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
193-204
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3701375-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:3701375-Autonomic Fibers, Preganglionic,
pubmed-meshheading:3701375-Autonomic Nervous System,
pubmed-meshheading:3701375-Autonomic Nervous System Diseases,
pubmed-meshheading:3701375-Cell Count,
pubmed-meshheading:3701375-Female,
pubmed-meshheading:3701375-Humans,
pubmed-meshheading:3701375-Male,
pubmed-meshheading:3701375-Middle Aged,
pubmed-meshheading:3701375-Motor Neurons,
pubmed-meshheading:3701375-Rectum,
pubmed-meshheading:3701375-Shy-Drager Syndrome,
pubmed-meshheading:3701375-Spinal Cord,
pubmed-meshheading:3701375-Urinary Bladder
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pubmed:year |
1986
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pubmed:articleTitle |
Shy-Drager syndrome and amyotrophic lateral sclerosis. Cytoarchitectonic and morphometric studies of sacral autonomic neurons.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|