Linked Life Data

3696296

Source:http://linkedlifedata.com/resource/pubmed/id/3696296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-2-2
pubmed:abstractText
A method for detecting the uptake of 125I-labeled monoclonal antibody by human tumors xenografted into nude mice is described. After implantation of the tumor intramuscularly in one of the forelimbs, radioactivity was measured in the area of tumor inoculation and in the contralateral normal forelimb. For these measurements, a lead apparatus was constructed which shielded over 99% of the whole body radioactivity and permitted efficient counting of 125I in the exposed portion of each forelimb. For each tumor an uptake ratio (UR) was calculated for the radioactivity in the tumor compared to muscle. With this shield apparatus, reproducible, sensitive and relatively rapid determinations of UR values can be obtained. Antibody localization can be detected in some tumors which are nonpalpable or very small and for tumors of up to 2 cm3 in volume. Whole-body radioactivity ranging from less than 0.037 MBq to higher levels suitable for radioimmunoscintigraphy could be utilized in this procedure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
A simple and sensitive method to measure radiolabeled antibody uptake by tumors in nude mice.
pubmed:affiliation
Cancer Research Laboratory, St. Joseph Hospital, Houston, TX 77002.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't