Linked Life Data

3692668

Source:http://linkedlifedata.com/resource/pubmed/id/3692668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-2-12
pubmed:abstractText
A series of dysgerminomas of the ovary was examined by electron microscopy and the findings were compared with germ cells in the normal developing ovary. The ultrastructural characteristics of the neoplastic cells, including prominent reticular nucleoli and sparsely distributed cytoplasmic organelles, indicated a close resemblance to oogonia present in the fetal ovary. Occasional cells had localized collections of glycogen, resembling primitive germ cells, but the irregular ameboid appearance and eccentric nuclear location characteristic of cells in the early stage were not seen. Ultrastructural features of oocyte differentiation, such as synaptinemal complexes and perinuclear arrangement of mitochondria, were not found in any of the tumors. Intercellular bridges, a frequent finding at the oogonial stage in the normal ovary, were absent in all of the tumors. The lack of intercellular communication could be responsible for uncontrolled mitotic division leading to germ cell neoplasia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0277-1691
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-31
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Comparative studies of normal and neoplastic ovarian germ cells: 2. Ultrastructure and pathogenesis of dysgerminoma.
pubmed:affiliation
Department of Pathology, University of Connecticut Health Center, Farmington.
pubmed:publicationType
Journal Article