Linked Life Data

3687839

Source:http://linkedlifedata.com/resource/pubmed/id/3687839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1987-12-24
pubmed:abstractText
The water extract of Hsien-Ho-T'sao (HHT) prolonged the tail bleeding time in conscious mice. This antihemostatic effect was dose-dependent and exhibited a biphasic pattern; i.e. its activity declined at doses higher than 0.5 mg/kg. the prolonged bleeding time persisted for at least 12 hr and maximal effect was observed at 3 hr after the oral administration of HHT 500 mg/kg. HHT was effective in preventing ADP-induced acute pulmonary thromboembolic death in mice, while aspirin and indomethacin had no effect on this model. HHT, like aspirin and indomethacin, also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death. All three drugs caused no significant protection in endotoxin shock. HHT was found to suppress platelet aggregation markedly, but little effect on blood coagulation. In conclusion, HHT was proved to be effective in the treatment of acute pulmonary thromboembolism, and this effect was mainly due to its antiplatelet action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-415X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effect of hsien-ho-t'sao (Agrimonia pilosa) on experimental thrombosis in mice.
pubmed:affiliation
Department of Biochemistry and Pharmacology, China Medical College, Taichung.
pubmed:publicationType
Journal Article