Linked Life Data

3686542

Source:http://linkedlifedata.com/resource/pubmed/id/3686542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-12-18
pubmed:abstractText
Parallel percutaneous absorption studies of two 14C-labelled chlorinated paraffins (C18, 50-53% chlorination; C28, 47% chlorination) were carried out in the Sprague-Dawley rat. The dermally applied dose (66 mg/cm2) was approximately equivalent to 2.0 g/kg of body weight. An oral absorption study with the C18-chlorinated paraffin (0.5 g/kg) was carried out in rats for comparison. Less than 1% of the dermally applied dose of [1-14C]polychlorooctadecane (50-53% chlorination) and less than 0.1% of the applied dose of [14,15-14C]polychlorooctacosane (47% chlorination) were recovered in excreta, expired air and tissues after 96 hours. In contrast, approximately 86% of the orally administered dose of [1-14C]polychlorooctadecane (0.5 g/kg) was recovered. These results indicate that rat skin acts as an effective barrier to chlorinated paraffins containing eighteen or more carbons and more than 40% chlorine by weight. The oral absorption of the C18 chlorinated paraffin can be estimated to be nearly 100 times greater than its dermal absorption. Based on current toxicity results from rodent experiments and these present findings, chlorinated paraffins of the type tested would be expected to have little or no effect in animals as a result of dermal exposure. It is reasonable to assume that such chlorinated paraffins are unlikely to be systemically toxic to humans by skin contact under normal conditions of production and use.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0748-2337
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Percutaneous and oral absorption of chlorinated paraffins in the rat.
pubmed:affiliation
Environmental and Health Science Laboratory, Mobil Oil Corporation, Princeton, NJ 08540.
pubmed:publicationType
Journal Article, Comparative Study