Linked Life Data

3669763

Source:http://linkedlifedata.com/resource/pubmed/id/3669763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-12-7
pubmed:abstractText
The natural killer (NK) activity of peripheral blood mononuclear cells against K562 targets was variable in 10 untreated patients with hairy cell leukemia and was inversely related to the number of hairy cells (HCs) present. After therapy with alpha-interferon (IFN-alpha) NK activity in vitro was equivalent to that of normal controls. It is suggested that the low activity often seen before treatment is attributable to dilution of NK cells by large numbers of inactive HCs and that this diluting effect is reduced as HCs disappear from the blood during IFN-alpha treatment. HCs was consistently resistant to NK lysis by normal or hairy cell leukemia allogeneic and autologous mononuclear cells, despite whether effector or target cells had been pretreated with IFN-alpha. Cold-target inhibition and direct binding experiments showed that HCs do not bind to NK effectors. It is therefore concluded that NK cells play no direct role in the progressive disappearance of HCs seen in patients receiving IFN-alpha.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
372-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The beneficial effects of alpha-interferon in hairy cell leukemia are not attributable to NK cell-mediated cytotoxicity.
pubmed:affiliation
Department of Haematology, University of Liverpool, Royal Liverpool Hospital, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't