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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-12-14
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pubmed:abstractText |
Troponin T (TNT) expressed in the developing chicken cardiac muscle was examined by immunoblotting combined with two-dimensional electrophoresis (2-D PAGE) and peptide mapping. When the whole lysate of the neonatal heart was examined by 2-D PAGE, two TNT variants were detected on the gel by monoclonal antibody to TNT. Expression of the two variants was developmentally regulated: one isoform (type I) was expressed from embryonic through neonatal stages, and the other (type II) from the late embryonic stage through adulthood during cardiac muscle development. The type-I isoform, but not type-II isoform, was also expressed transiently in chicken skeletal muscle at embryonic stages. As judged from the peptide maps, the two isoforms differed in the N-terminal region but not in the C-terminal region.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-924X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3667565-Aging,
pubmed-meshheading:3667565-Animals,
pubmed-meshheading:3667565-Antibodies, Monoclonal,
pubmed-meshheading:3667565-Chick Embryo,
pubmed-meshheading:3667565-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3667565-Genetic Variation,
pubmed-meshheading:3667565-Heart,
pubmed-meshheading:3667565-Peptide Mapping,
pubmed-meshheading:3667565-Troponin,
pubmed-meshheading:3667565-Troponin T
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pubmed:year |
1987
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pubmed:articleTitle |
Identification of two variants of troponin T in the developing chicken heart using a monoclonal antibody.
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pubmed:affiliation |
Department of Biology, Faculty of Science, Chiba University.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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