Linked Life Data

3657928

Source:http://linkedlifedata.com/resource/pubmed/id/3657928

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1987-10-30
pubmed:abstractText
Potentially pathogenic bacteria and yeasts meet a number of resistance factors. These colonization resistance (CR) determining factors control the growth density of potentially pathogenic microorganisms in the various parts of the alimentary canal. The CR of the digestive tract is to be seen partially of host origin but to a greater extent due to direct and indirect activity of the (anaerobic) indigenous microflora. This implies that the CR mechanism is vulnerable to antibiotics which affect the indigenous flora during treatment. A decreased CR enhances colonization by microorganisms that are resistant to the antibiotic(s) used for therapy. Increased population densities of potentially pathogenic bacteria ("overgrowth") may correlate with invasion of the mucosal tissues often followed by translocation to remote lymphatic organs. Overgrowth also may correlate with development or acquisition of resistance to the antibiotic applied. By screening in experimental animals antibiotics have been selected which do not affect the CR. Such antimicrobial drugs have successfully been used to selectively eliminate potentially pathogenic bacteria and yeast in neutropenic patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0027-769X
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-17
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Colonization resistance of the digestive tract--mechanism and clinical consequences.
pubmed:affiliation
Laboratory for Medical Microbiology, University Hospital, Groningen, The Netherlands.
pubmed:publicationType
Journal Article