Linked Life Data

3653295

Source:http://linkedlifedata.com/resource/pubmed/id/3653295

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-11-16
pubmed:abstractText
It has been suggested that in immediate hypersensitivity of the guinea-pig conjunctiva, induced by the topical application of an antigen, the antigen is selectively taken up by the conjunctiva-associated lymphoid tissue. We tested this hypothesis by applying horseradish peroxidase (HRP) to the guinea-pig conjunctiva and studying its uptake by light- and electron microscopy. As early as 30 min after the application of the HRP, precipitate indicating the presence of HRP could be seen in the epithelial cells in membrane limited granules in the non-lymphoid and lymphoid epithelium. There was no selective uptake of HRP by the lymphoid-associated epithelial cells. We hypothesize that the epithelial cells of the conjunctiva, in contrast to those of the small intestine, phagocytose antigen and transfer it directly to the substantia propria of the conjunctiva for local immunologic processing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-37
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The uptake of horseradish peroxidase by the conjunctival epithelium of the guinea-pig.
pubmed:affiliation
Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois 60611.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't