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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1987-10-22
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pubmed:abstractText |
The feasibility of employing the rat as an experimental model for investigation of full-dose heparin anticoagulation was assessed. Striking similarities were found to exist between rats and humans regarding baseline-activated partial thromboplastin time (APTT) values, and dosage per kilogram of heparin required to produce an APTT value of 1 1/2-3 times normal, the clinical definition of full-dose heparinization. Based upon these similarities, it appears that the rat can effectively serve as an experimental model for investigating the effects of heparin in humans.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0301-0147
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
206-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3623264-Animals,
pubmed-meshheading:3623264-Blood Coagulation,
pubmed-meshheading:3623264-Dose-Response Relationship, Drug,
pubmed-meshheading:3623264-Drug Administration Schedule,
pubmed-meshheading:3623264-Heparin,
pubmed-meshheading:3623264-Humans,
pubmed-meshheading:3623264-Male,
pubmed-meshheading:3623264-Models, Biological,
pubmed-meshheading:3623264-Partial Thromboplastin Time,
pubmed-meshheading:3623264-Rats
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pubmed:year |
1987
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pubmed:articleTitle |
Examination of the utility of the rat as an animal model for human anticoagulation.
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pubmed:publicationType |
Journal Article,
Comparative Study
|