Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1987-9-21
|
pubmed:abstractText |
A series of substituted 2-pyridyl-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-ones 1-24 were synthesized and evaluated for positive inotropic activity. In rats, cats, and dogs most of these tricyclic heterocycles produced a dose-related increase in myocardial contractility with little effect on heart rate and blood pressure. The increase in contractility was not mediated via stimulation of beta-adrenergic receptors. Compound 1 (BM 14.478) was more potent than milrinone (25) and enoximone when administered intravenously to rats, cats, and dogs. After oral administration of 1 mg/kg, compound 1, milrinone, and pimobendan were equipotent. However, only 1 and pimobendan were still active after 6 h. The structural requirements necessary for optimal cardiotonic activity within this novel class of heterocycles were investigated.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
30
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1279-87
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:3612681-Animals,
pubmed-meshheading:3612681-Benzimidazoles,
pubmed-meshheading:3612681-Blood Pressure,
pubmed-meshheading:3612681-Cardiotonic Agents,
pubmed-meshheading:3612681-Cats,
pubmed-meshheading:3612681-Chemical Phenomena,
pubmed-meshheading:3612681-Chemistry,
pubmed-meshheading:3612681-Dogs,
pubmed-meshheading:3612681-Dose-Response Relationship, Drug,
pubmed-meshheading:3612681-Female,
pubmed-meshheading:3612681-Heart Rate,
pubmed-meshheading:3612681-Male,
pubmed-meshheading:3612681-Myocardial Contraction,
pubmed-meshheading:3612681-Pyridines,
pubmed-meshheading:3612681-Pyrroles,
pubmed-meshheading:3612681-Rats,
pubmed-meshheading:3612681-Stimulation, Chemical,
pubmed-meshheading:3612681-Structure-Activity Relationship
|
pubmed:year |
1987
|
pubmed:articleTitle |
Nonsteroidal cardiotonics. 1. 2-Pyridyl-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-ones, a novel class of cardiotonic agents.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|