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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1987-8-28
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pubmed:abstractText |
Six eyes with persistent corneal epithelial defects of various etiologies were treated in a randomized, prospective, double-masked study to evaluate the effect of fibronectin on corneal epithelial wound healing. Study eyes received homologous human fibronectin (300 micrograms/ml), mixed with gentamicin and artificial tears, 4 times a day. Control eyes received the mixture of gentamicin and artificial tears. If no healing occurred after 2 weeks, the drug was unmasked and where control drops had been given, the mixture containing fibronectin was administered in open-label fashion. All 4 eyes in diabetic patients had successful epithelial healing when treated with the fibronectin solution. The 2 remaining corneas, which had defects secondary to a thermal injury and a presumed infectious etiology, did not heal with fibronectin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0277-3740
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
128-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3608513-Adult,
pubmed-meshheading:3608513-Aged,
pubmed-meshheading:3608513-Corneal Diseases,
pubmed-meshheading:3608513-Diabetes Complications,
pubmed-meshheading:3608513-Double-Blind Method,
pubmed-meshheading:3608513-Drug Evaluation,
pubmed-meshheading:3608513-Epithelial Cells,
pubmed-meshheading:3608513-Epithelium,
pubmed-meshheading:3608513-Female,
pubmed-meshheading:3608513-Fibronectins,
pubmed-meshheading:3608513-Humans,
pubmed-meshheading:3608513-Male,
pubmed-meshheading:3608513-Middle Aged,
pubmed-meshheading:3608513-Random Allocation,
pubmed-meshheading:3608513-Wound Healing
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pubmed:year |
1987
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pubmed:articleTitle |
Application of homologous fibronectin to persistent human corneal epithelial defects.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Case Reports,
Research Support, Non-U.S. Gov't
|