Linked Life Data

3607880

Source:http://linkedlifedata.com/resource/pubmed/id/3607880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-9-24
pubmed:abstractText
Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences. One of these factors is closely related or identical to nuclear factor 1 (NF1). Extracts from nonhepatic tissues or from dedifferentiated hepatoma cells that do not transcribe the albumin gene display a different pattern of DNA-protein interactions. Mixing experiments show that the variant pattern of dedifferentiated cells is dominant over that of differentiated ones, suggesting that nonexpressing cells contain dominant negatively acting factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
627-38
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Factors involved in control of tissue-specific expression of albumin gene.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't