Linked Life Data

3596990

Source:http://linkedlifedata.com/resource/pubmed/id/3596990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1987-8-4
pubmed:abstractText
Vitreous and macrophage samples were tested for the ability to stimulate proliferation and cell migration in cultured rabbit retinal pigment epithelium (RPE). A macrophage invasion was elicited by the intravitreal injection of latex particles in rabbits and after 3 days the vitreal macrophages were collected. The macrophages themselves, macrophage-conditioned culture medium, and macrophage-incubated vitreous had modest effects on RPE proliferation, but significantly stimulated RPE migration. A portion of the migration activity may be due to macrophage-derived proteases acting on normal vitreous. Mitogenic and additional migration-stimulating activity may also arise from adjacent tissues or from a breakdown of the blood-vitreous barrier that accompanies a macrophage invasion. A macrophage ingress into the vitreous may provide part of the stimulation for the migration and proliferation of RPE in conditions such as proliferative vitreoretinopathy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1100-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Vitreous macrophage elicitation: generation of stimulants for pigment epithelium in vitro.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't