Linked Life Data

3594515

Source:http://linkedlifedata.com/resource/pubmed/id/3594515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-8-10
pubmed:abstractText
The characteristics of long-duration inhibitory postsynaptic potentials (1-IPSPs) which are evoked in rat frontal neocortical neurons by local electrical stimulation were investigated with intracellular recordings from an in vitro slice preparation. Stimulation with suprathreshold intensities evoked 1-IPSPs with typical durations of 600-900 msec at resting membrane potential. Conductance increases of 15-60% were measured at the peak amplitude of 1-IPSPs (150-250 msec poststimulus). The duration of the conductance increases during 1-IPSPs displayed a significant voltage dependence, decreasing as the membrane potential was depolarized and increasing with hyperpolarization. The reversal potential of 1-IPSPs is significantly altered by reductions in the extracellular potassium concentration. Therefore it is concluded that 1-IPSPs in rat neocortical neurons are generated by the activation of a potassium conductance. 1-IPSPs exhibit stimulation fatigue. Stimulation with a frequency of 1 Hz produces a complete fatigue of the conductance increases during 1-IPSPs after approximately 20 consecutive stimuli. Recovery from this fatigue requires minutes. 1-IPSPs are not blocked by bicuculline but are blocked by baclofen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0272-4340
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-18
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neurons in vitro.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't