Linked Life Data

3593322

Source:http://linkedlifedata.com/resource/pubmed/id/3593322

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1987-6-26
pubmed:abstractText
Adherence of normal human erythrocytes to cultured endothelial cells when exposed to in vitro fluid shear forces typical of venules, capillaries and arterioles is very low, less than 0.03 percent, in the presence of an albumin-buffer but increases five fold by the effects of autologous plasma. Senescent erythrocytes obtained by density separation had an adherence frequency in the normal cell range, suggesting that predisposition to endothelial adherence is not a key factor in regulation of life span by the sequestration, identification and phagocytosis modulated by immune recognition. Sickle cells' frequency of adherence exceeds that of normal cells particularly at low shear forces calculated to resemble those of veins and sinuses, and increases five to ten fold when autologous plasma obtained during sickle crisis is present; these findings add support to the hypothesis that excessive tendency for sickle cell adherence may contribute to the vascular obstructive phenomena of the disorder. The behavior of hereditary spherocytes and thalassemic erythrocytes resembles normal cells, suggesting that hemolytic mechanisms are not significantly dependent on erythrocyte-endothelial cell interaction. Erythrocytes from patients having diabetes exhibit the characteristics of control cells, suggesting that their membrane adhesion to endothelium may not be critical to initiation of vessel wall pathophysiological processes; however, the behavior in relation to damaged endothelial cells may differ importantly.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S93-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Erythrocyte-endothelial cell adherence in senescence and in hemolytic disorders.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.