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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
4395
|
|
pubmed:dateCreated |
1979-7-28
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|
pubmed:abstractText |
Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40% decrease in the density of beta1-adrenergic receptors in the cerebral cortex but had no effect on the density of beta2-adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64% increase in the density of beta1-adrenergic receptors in adult cerebral cortex with no change in the density of beta2-adrenergic receptors. These results suggest that the beta-adrenergic receptors in rat cortex involved in neuronal function are primarily of the beta1 subtype.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
25
|
|
pubmed:volume |
204
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
866-8
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:35829-Adrenergic beta-Agonists,
pubmed-meshheading:35829-Animals,
pubmed-meshheading:35829-Binding, Competitive,
pubmed-meshheading:35829-Cerebral Cortex,
pubmed-meshheading:35829-Cyclic AMP,
pubmed-meshheading:35829-Desipramine,
pubmed-meshheading:35829-Hydroxydopamines,
pubmed-meshheading:35829-Kinetics,
pubmed-meshheading:35829-Rats,
pubmed-meshheading:35829-Receptors, Adrenergic,
pubmed-meshheading:35829-Receptors, Adrenergic, beta
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pubmed:year |
1979
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pubmed:articleTitle |
beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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