Linked Life Data

3581580

Source:http://linkedlifedata.com/resource/pubmed/id/3581580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
219
pubmed:dateCreated
1987-7-6
pubmed:abstractText
Stress deprivation alters the morphologic, biochemical, and biomechanical characteristics of various components of synovial joints. Prominent among the protean changes that result are proliferation of fibrofatty connective tissue within the joint space, adhesions between synovial folds, adherence of fibrofatty connective tissue to cartilage surfaces, atrophy of cartilage, "ulceration" at points of cartilage-cartilage contact, disorganization of cellular and fibrillar ligament alignment, weakening of ligament insertion sites owing to osteoclastic resorption of bone and Sharpey's fibers, regional osteoporosis of the involved extremity, increased force requirement for joint cycling, and increased ligament compliance. Reduced load-to-failure and reduced energy-absorbing capacity of the bone-ligament-bone complex progresses to about one-third that of controls. Collagen mass declines by about 10%. Collagen turnover increases with accelerated degradation and synthesis. Formation of reducible collagen crosslinks increases. Content of proteoglycan, notably hyaluronic acid, falls and water content is correspondingly reduced. An understanding of the functional implications of these extensive perturbations in the phenomenon of joint immobilization is essential for progress in orthopedics.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of immobilization on joints.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.