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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1987-6-9
|
| pubmed:abstractText |
Anti-myelin antibodies (AMA) of IgG, IgM, and IgA class were investigated by ELISA in CSF and serum from patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (GBB), other inflammatory diseases of the nervous system (ID) comprising meningoencephalitis (ME), multiple sclerosis (MS), and Guillain-Barré syndrome (GBS), and various noninflammatory neurological diseases (NID). Anti-Borrelia antibodies (ABA) were determined by ELISA in GBB patients. In CSF, a high incidence of IgG-AMA, IgM-AMA, and IgA-AMA was found in GBB as compared with ID and NID. On average, positive AMA titers were higher in GBB than in ID and NID, IgM-AMA titers in GBB being most prominent. In serum, AMA were found in all but 2 patients investigated. On average, IgM-AMA titers were higher in GBB and MS than in other diseases; IgG-AMA titers in GBB and ME were relatively low. Antibody indices, calculated from titer values and Ig concentrations in CSF and serum, indicate intrathecal synthesis mainly of IgG- and IgA-AMA, and of IgG- and IgM-ABA. Participation of AMA in the pathogenesis of GBB may be envisaged, but needs further confirmation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0176-6724
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
263
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
160-8
|
| pubmed:dateRevised |
2009-6-8
|
| pubmed:meshHeading |
pubmed-meshheading:3577478-Antibodies, Bacterial,
pubmed-meshheading:3577478-Autoantibodies,
pubmed-meshheading:3577478-Borrelia,
pubmed-meshheading:3577478-Demyelinating Diseases,
pubmed-meshheading:3577478-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:3577478-Humans,
pubmed-meshheading:3577478-Immunoglobulin A,
pubmed-meshheading:3577478-Immunoglobulin G,
pubmed-meshheading:3577478-Immunoglobulin M,
pubmed-meshheading:3577478-Immunoglobulins,
pubmed-meshheading:3577478-Lyme Disease,
pubmed-meshheading:3577478-Meningitis,
pubmed-meshheading:3577478-Meningoencephalitis,
pubmed-meshheading:3577478-Multiple Sclerosis,
pubmed-meshheading:3577478-Myelin Sheath,
pubmed-meshheading:3577478-Nervous System Diseases,
pubmed-meshheading:3577478-Polyneuropathies,
pubmed-meshheading:3577478-Polyradiculoneuropathy
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Anti-myelin antibodies in cerebrospinal fluid and serum of patients with meningopolyneuritis Garin-Bujadoux-Bannwarth and other neurological diseases.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|