Linked Life Data

3575245

Source:http://linkedlifedata.com/resource/pubmed/id/3575245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-5-28
pubmed:abstractText
Upon intraperitoneal administration of N-(1-14C)-acetylpenicillamine (NAPA) to rats, at a dose of 1-2 mmol/kg body weight, a 14C-labelled metabolite of NAPA together with unchanged NAPA were excreted in bile. The NAPA metabolite was characterized by acid hydrolysis and thin-layer chromatography. Rats previously depleted of liver glutathione by intraperitoneal injection of cyclohexene oxide, 2.5 mmol/kg body weight, were given intraperitoneal injections of 14C-cysteine, 0.5 mmol/kg, or 14C-NAPA, 1-2 mmol/kg, together with 1-chloro-2,4-dinitrobenzene (DNB), 1 mmol/kg, or bromosulphophtalein (BSP), 0.5 mmol/kg body weight. Simultaneous administration of 14C-cysteine and DNB or BSP lead to rapid incorporation of 14C-activity in glutathione and glutathione conjugates of DNB and BSP being excreted in bile. Upon simultaneous administration of 14C-NAPA and DNB or BSP, 14C-labelled metabolite of NAPA not conjugated to DNB or BSP, and unchanged NAPA, together with non-labelled glutathione conjugates of DNB or BSP, were excreted in bile. This is interpreted as indicating that neither NAPA nor NAPA metabolite are capable of forming conjugates of DNB or BSP in rat liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0901-9928
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Metabolization of 14C-N-acetylpenicillamine and 14C-cysteine in relation to 1-chloro-2,4-dinitrobenzene and sulphobromophtalein conjugation and biliary excretion in the rat.
pubmed:publicationType
Journal Article