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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-6-9
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pubmed:abstractText |
A sialidase-susceptible monosialoganglioside was isolated from normal human brain by DEAE-Sephadex A-25 and Iatrobeads column chromatography. The yield of this ganglioside was about 6 mg per whole brain. Its structure was elucidated by sugar analysis, sialidase digestion, permethylation, and proton NMR studies. This ganglioside had carbohydrate, fatty acid, and long-chain base compositions identical to those of brain GM1a. However, the sialosyl residue was found to be linked (alpha 2-3) to the terminal galactosyl residue of the asialo-GM1a backbone. The complete structure of this ganglioside was therefore identified as GM1b or IV3NeuAcGgOse4Cer.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2275
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3572254-Adult,
pubmed-meshheading:3572254-Brain Chemistry,
pubmed-meshheading:3572254-Carbohydrate Conformation,
pubmed-meshheading:3572254-Carbohydrate Sequence,
pubmed-meshheading:3572254-G(M1) Ganglioside,
pubmed-meshheading:3572254-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:3572254-Humans,
pubmed-meshheading:3572254-Magnetic Resonance Spectroscopy
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pubmed:year |
1987
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pubmed:articleTitle |
Isolation and characterization of ganglioside GM1b from normal human brain.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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