Linked Life Data

3566314

Source:http://linkedlifedata.com/resource/pubmed/id/3566314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-5-8
pubmed:abstractText
After completion of treatment with growth hormone (GH) 19 patients with isolated 'idiopathic' GH deficiency and 15 with post-irradiation GH deficiency underwent retesting of GH secretion with an insulin tolerance test or an arginine stimulation test, or both. Patients with post-irradiation GH deficiency comprised 13 patients with central nervous system tumours distant from the hypothalamo-pituitary axis and two with acute lymphoblastic leukaemia, who had received cranial or craniospinal irradiation. All 15 patients with post-irradiation GH deficiency remained GH deficient (peak GH response less than 7 mU/l (n = 10) and 7-15 mU/l (n = 5)). Of the 19 retested patients with idiopathic GH deficiency, however, five (26%) had peak GH responses of greater than 15 mU/l (regarded now as transient or false idiopathic GH deficiency) and were indistinguishable from the remainder (permanent or true idiopathic GH deficiency, peak GH responses less than 7 mU/l (n = 12) and 7-15 mU/l (n = 2)), by pretreatment anthropometry and post-treatment height standard deviation score, but had a lower first year height velocity (mean (SD) velocity 5.6 (0.5) cm/year for false idiopathic deficiency v 8.7 (1.75) cm/year for true idiopathic deficiency, p less than 0.01) and height increment on treatment (mean (SD) increment 2.2 (1.5) cm/year for false idiopathic deficiency v 5.2 (2.3) cm/year for true idiopathic deficiency, p less than 0.05). By current practices two patients with false idiopathic deficiency may have been distinguished by sex steroid priming. Thus post-irradiation GH deficiency seems to be permanent, but errors in diagnosis in idiopathic GH deficiency are common.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-221628, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-229995, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-263308, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-4015164, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-4062345, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-5008234, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-5288779, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-576178, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-6363657, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-6696487, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-6708271, http://linkedlifedata.com/resource/pubmed/commentcorrection/3566314-849990
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1468-2044
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Growth hormone state after completion of treatment with growth hormone.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't