Linked Life Data

3564830

Source:http://linkedlifedata.com/resource/pubmed/id/3564830

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-5-14
pubmed:abstractText
The particular questions asked in our study were: 1. does the individual reproducibility of the cardiovascular reflex tests differ between healthy controls and patients suffering from type I diabetes mellitus and 2. if there is a difference, do the different cardiovascular reflexes vary in this regard? Nine healthy controls (4 women, 5 men, age 31 +/- 2.1 years) and 11 type I diabetics (4 women, 7 men, age 30.9 +/- 5.6 years, duration of diabetes 3.23 years) underwent the following tests 6 times in a 12-h period (07:00 to 19:00): variation of heart rate during deep breathing (E/I ratio), variation of heart rate during lying and standing (tachycardia/bradycardia or 30/15 ratio), Valsalva maneuver (Valsalva ratio), response of diastolic blood pressure to sustained hand grip, and response of systolic blood pressure to posture. The test results did not indicate a diurnal fluctuation nor were they systematically influenced by antecedent insulin injections or meals, either in diabetic patients or in healthy controls. The 11 diabetics had significantly lower intraindividual variations of E/I and Valsalva ratios than the controls (p less than 0.05, p less than 0.001, respectively). In the diabetics with parasympathetic failure the intraindividual variabilities of all cardiovascular reflex responses were lower than those of the patients with an intact autonomic nervous system as well as those of the control subjects. On the contrary, in the diabetic patients without autonomic neuropathy, only the intraindividual variability of the Valsalva maneuver was significantly attenuated (p less than 0.025), compared with the healthy volunteers. To conclude, the more pathological the single test result, the greater is its reproducibility and its clinical significance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0001-5563
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-89
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Reduced intraindividual variability of repeated cardiovascular reflex tests: an additional marker of autonomic neuropathy in insulin-dependent (type I) diabetes mellitus?
pubmed:publicationType
Journal Article