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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-3-11
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pubmed:abstractText |
Muscarinic receptor-linked increases in intracellular free Ca2+ as measured with quin-2 and Ca2+ release from monolayers of cells have been measured in the human neuroblastoma cell line SH-SY5Y. Induction of differentiation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) leads to a decrease in the sensitivity of the cells to low concentrations of agonists with respect to the induced increase in cytosolic free Ca2+ and stimulation of Ca2+ efflux. No decrease in agonist binding affinity was observed when the displacement of a labelled antagonist, 3H-NMS, by a non-labelled agonist was studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3543028-Calcium,
pubmed-meshheading:3543028-Cell Differentiation,
pubmed-meshheading:3543028-Cell Line,
pubmed-meshheading:3543028-Humans,
pubmed-meshheading:3543028-Kinetics,
pubmed-meshheading:3543028-Methacholine Chloride,
pubmed-meshheading:3543028-Methacholine Compounds,
pubmed-meshheading:3543028-N-Methylscopolamine,
pubmed-meshheading:3543028-Neuroblastoma,
pubmed-meshheading:3543028-Receptors, Muscarinic,
pubmed-meshheading:3543028-Scopolamine Derivatives
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pubmed:year |
1987
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pubmed:articleTitle |
Differentiation-associated decrease in muscarinic receptor sensitivity in human neuroblastoma cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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