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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-1-28
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pubmed:abstractText |
In an examination of the relationships among plasma aminoglycoside concentrations, the minimal inhibitory concentration (MIC) for the infecting organism, and therapeutic outcome, data were analyzed from 236 patients with gram-negative bacterial infections who were participants in four clinical trials of gentamicin, tobramycin, and amikacin. Clinical response to therapy occurred in 188 (80%) patients. Elevated maximal and mean peak aminoglycoside concentration/MIC ratios were strongly associated with clinical response (P less than .00001 and P less than .0001, respectively). A graded dose-response effect was found between an increasing maximal peak concentration/MIC ratio and clinical response. By logistic regression the peak concentration/MIC ratios were associated significantly with clinical response after adjustment for underlying severity of illness and other factors correlated with response. These results demonstrate that a high peak concentration relative to the MIC for the infecting organism is a major determinant of the clinical response to aminoglycoside therapy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3540140-Adult,
pubmed-meshheading:3540140-Aged,
pubmed-meshheading:3540140-Aged, 80 and over,
pubmed-meshheading:3540140-Amikacin,
pubmed-meshheading:3540140-Bacterial Infections,
pubmed-meshheading:3540140-Clinical Trials as Topic,
pubmed-meshheading:3540140-Double-Blind Method,
pubmed-meshheading:3540140-Female,
pubmed-meshheading:3540140-Gentamicins,
pubmed-meshheading:3540140-Gram-Negative Bacteria,
pubmed-meshheading:3540140-Humans,
pubmed-meshheading:3540140-Male,
pubmed-meshheading:3540140-Microbial Sensitivity Tests,
pubmed-meshheading:3540140-Middle Aged,
pubmed-meshheading:3540140-Random Allocation,
pubmed-meshheading:3540140-Tobramycin
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pubmed:year |
1987
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pubmed:articleTitle |
Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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