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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1987-1-14
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pubmed:abstractText |
Uromodulin, an 85-kDa glycoprotein isolated from pregnancy urine, has been shown to inhibit antigen-induced proliferation of human lymphocytes in vitro. The present investigation was undertaken to determine its mechanism of action. Uromodulin was found to be a potent inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. Uromodulin was compared to a previously described 30- to 35-kDa IL-1 inhibitor isolated from urine of febrile patients (febrile inhibitor). Uromodulin and the febrile inhibitor blocked the effects of both human IL-1 and recombinant murine IL-1, but the activity of uromodulin was greater than that of the only partially purified febrile inhibitor preparation. However, in contrast to the febrile inhibitor, uromodulin markedly enhanced interleukin 2-induced thymocyte proliferation. Antigenic analysis of the two preparations by ELISA and immunoblot analysis demonstrated that the febrile inhibitor did not cross-react with uromodulin using monoclonal or polyclonal antisera. These findings indicate that uromodulin is a potent IL-1 inhibitor that is probably distinct from the IL-1 inhibitor derived from the urine of febrile individuals. Whether this IL-1 inhibitory activity underlies its immunosuppressive activity on human lymphocytes remains to be established.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-133763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-2409603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-2578047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-2985700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-3160805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-334103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-3872905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-4204102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-578671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6157723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6175245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6209582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6327874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6334714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6339079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6369481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6601995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6602846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6607312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6609981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6795276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6982471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-6982930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3538018-7389211
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9119-23
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3538018-Antibodies, Monoclonal,
pubmed-meshheading:3538018-Female,
pubmed-meshheading:3538018-Fever,
pubmed-meshheading:3538018-Humans,
pubmed-meshheading:3538018-Immunologic Techniques,
pubmed-meshheading:3538018-Interleukin-1,
pubmed-meshheading:3538018-Lymphocyte Activation,
pubmed-meshheading:3538018-Molecular Weight,
pubmed-meshheading:3538018-Mucoproteins,
pubmed-meshheading:3538018-Pregnancy,
pubmed-meshheading:3538018-Pregnancy Proteins,
pubmed-meshheading:3538018-Uromodulin
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pubmed:year |
1986
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pubmed:articleTitle |
Uromodulin, an immunosuppressive protein derived from pregnancy urine, is an inhibitor of interleukin 1.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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