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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1986-11-28
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pubmed:abstractText |
The predictive value of the dexamethasone suppression test (DST) was evaluated in two consecutive double-blind, placebo-controlled trials evaluating 61 depressed inpatients randomized to either one of two drugs, sertraline or oxaprotiline, or placebo over a 4-week clinical trial. For 30 patients who completed at least 3 weeks of double-blind treatment on either drug, the initial DST was not predictive of response to drug treatment. For the 17 patients who completed at least 3 weeks of double-blind treatment on placebo, the presence of a positive DST predicted a statistically significantly poorer response to placebo as opposed to a negative DST. These preliminary findings suggest that for depressed individuals who present with a positive DST, remission without active medication is less likely and somatic treatment should be considered.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Naphthylamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Maprotiline,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos,
http://linkedlifedata.com/resource/pubmed/chemical/Sertraline,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxymaprotilin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0271-0749
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
6
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
286-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3534005-1-Naphthylamine,
pubmed-meshheading:3534005-Clinical Trials as Topic,
pubmed-meshheading:3534005-Depressive Disorder,
pubmed-meshheading:3534005-Dexamethasone,
pubmed-meshheading:3534005-Double-Blind Method,
pubmed-meshheading:3534005-Humans,
pubmed-meshheading:3534005-Maprotiline,
pubmed-meshheading:3534005-Placebos,
pubmed-meshheading:3534005-Sertraline
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pubmed:year |
1986
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pubmed:articleTitle |
The dexamethasone suppression test and response to placebo.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|