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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1986-11-18
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pubmed:databankReference |
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pubmed:abstractText |
Protooncogenes when transduced by retroviruses may undergo structural modifications that render their gene products oncogenic. The c-fms gene encodes a transmembrane protein with tyrosine kinase activity that is very similar or identical to the receptor for the monocyte-macrophage colony-stimulating factor. Its transforming homologue (v-fms) in the Susan McDonough strain feline sarcoma virus causes fibrosarcomas in cats. Molecular cloning and sequence analysis of the cDNA that encodes the cytoplasmic domain of the human c-fms gene shows that the product of the transduced viral homologue, v-fms, is truncated at the COOH-terminal end. The COOH-terminal 40 amino acids of the c-fms gene product are replaced in the v-fms gene product by 11 amino acids encoded by the retroviral genome. Hybrid v-fms/c-fms genes, in which either the entire cytoplasmic domain or the COOH-terminal coding sequences of the v-fms gene were replaced by the corresponding segments of the c-fms gene, had a reduced ability to transform fibroblasts despite a high level of encoded protein on the cell surface. These data indicate that the COOH-terminal modifications contribute to the transforming potential of the v-fms viral oncogene product.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-172908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-210957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-230490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2408759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2420005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2421165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2580348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2582237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2869410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2987679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-2992362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3010289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3018521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3018522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3484837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3856862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3871440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-3986905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-4028159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6087323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6094011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6154869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6193890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6204766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6275118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6281462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6286831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6291048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6292527,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6309409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6309875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6313229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6322166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6328312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6354303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6381756,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6498333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6579837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6582485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6594680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3532121-6978185
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7800-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3532121-Amino Acid Sequence,
pubmed-meshheading:3532121-Cell Line,
pubmed-meshheading:3532121-Cell Transformation, Neoplastic,
pubmed-meshheading:3532121-DNA,
pubmed-meshheading:3532121-Humans,
pubmed-meshheading:3532121-Molecular Sequence Data,
pubmed-meshheading:3532121-Mutation,
pubmed-meshheading:3532121-Oncogene Proteins, Viral,
pubmed-meshheading:3532121-Proto-Oncogene Proteins,
pubmed-meshheading:3532121-Receptor, Epidermal Growth Factor,
pubmed-meshheading:3532121-Structure-Activity Relationship,
pubmed-meshheading:3532121-Transduction, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
"Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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