Linked Life Data

352963

Source:http://linkedlifedata.com/resource/pubmed/id/352963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-9-30
pubmed:abstractText
The bronchopulmonary cellular immunological response to repeated intratracheal inoculation of aluminum chlorhydrate, sodium zirconium lactate, and zirconium aluminum glycine was examined in rabbits. Results of a dose-response experiment using 0.1, 1.0, and 10.0-mg intratracheal inoculations of each metallic salt demonstrated significant bronchopulmonary histopathology in the 10.0-mg dose-response groups only. Acute lesions were histologically characterized by an inflammatory response centered around respiratory bronchioles. Although epithelioid cell formation was evident in 10.0 mg of aluminum salt (aluminum chlorhydrate and zirconium aluminum glycine) -injected animals, no well-defined granulomas characterized by an orderly arrangement of epithelioid cells, lymphocytes, and giant cells were evident in any of the experimental groups employed. All three metallic salts induced "activated" bronchopulmonary macrophages as determined by an in vitro phagocytic assay. This activation was likely nonimmunological since no measurable differences were observed in metallic salt-induced delayed skin reactivity or migration inhibition factor production between inoculated and uninoculated rabbits. The above observations suggest that aluminum and zirconium salts administered in comparatively high dosage via the respiratory tract route can induce respiratory bronchiolitis and activation of alveolar macrophages in the absence of demonstrable delayed hypersensitivity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-13523057, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-13727273, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-14015998, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-14057635, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-14851204, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-16557782, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-239059, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-4102688, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-4200649, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-4829086, http://linkedlifedata.com/resource/pubmed/commentcorrection/352963-5005299
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
847-52
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Bronchopulmonary cellular response to aluminum and zirconium salts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.