Linked Life Data

3528880

Source:http://linkedlifedata.com/resource/pubmed/id/3528880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-10-21
pubmed:abstractText
Hemodynamic and hormonal actions of acute (50 mg) and chronic (150 mg/day) captopril were tested in 10 patients with essential hypertension. Under short-term conditions blood pressure was reduced, heart rate and plasma adrenaline did not change, plasma angiotensin II and plasma aldosterone decreased. Plasma renin activity, basal plasma noradrenaline and bicyclo-PGEm, a novel stable metabolite of prostaglandin E2, increased after captopril. With chronic captopril treatment blood pressure was reduced after 4 weeks before readministration of captopril, heart rate did not change, plasma renin activity and bicyclo-PGEm remained elevated for 12 h after the last captopril dose. Angiotensin II remained suppressed, aldosterone and plasma catecholamines did not change between doses. Readministration of captopril led to a further reduction in blood pressure. Angiotensin II and aldosterone were further suppressed, bicyclo-PGEm levels increased from a higher baseline. Heart rate and plasma catecholamines did not change. Taken together, the results suggest that prostaglandin E2 is involved in the acute and chronic hypotensive response of captopril in patients with essential hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2766
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Acute and chronic effects of captopril on bicyclo-PGEm, the stable bicyclic end product of prostaglandin E2 in essential hypertension.
pubmed:publicationType
Journal Article