Linked Life Data

3525204

Source:http://linkedlifedata.com/resource/pubmed/id/3525204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1986-9-17
pubmed:abstractText
Human bone marrow fibroblasts (BMF) regulate the proliferation of granulocyte and macrophage colony-forming cells (GM-CFC). The mechanism used by BMF to regulate the proliferation of GM-CFC was investigated. When target marrows contained few spontaneous colonies, BMF enhanced granulopoiesis, while BMF-conditioned medium (BMF-CM) failed to do so. When target marrows contained large numbers of spontaneous colonies and when colony-stimulating factor (CSF) was present in the cultures, BMF and BMF-CM inhibited granulopoiesis. Adherent cells were necessary for the stimulation of granulopoiesis by BMF, but not for the inhibition of granulopoiesis by BMF and BMF-CM. Interaction of BMF with GM-CFC in dishes for a short time inhibited colony formation by GM-CFC. From these data, it has been concluded that the BMF regulate granulopoiesis and maintain the homeostasis of granulopoiesis through cell-cell interaction and factors produced by the BMF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
696-701
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Regulatory role of human bone marrow fibroblasts in proliferation by granulocyte and macrophage colony-forming cells.
pubmed:publicationType
Journal Article