Linked Life Data

3518245

Source:http://linkedlifedata.com/resource/pubmed/id/3518245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-6-9
pubmed:abstractText
Since the original discovery and structural characterization of leukotrienes, these substances have attracted considerable interest due to their numerous biological activities. It is known that these substances exert a short lasting vasoconstrictory and a longer lasting vasodilatory response. However, the cause of this biphasic response is not clear as yet. Human coronary artery segments synthesize about 50 pg PGI2/cm2/min in vitro under pressure perfusion. At concentrations ranging from 1 to 100 ng leukotrienes C4 and D4 cause a dose-dependent increase in PGI2 generation. Inhibition by acetylsalicylic acid and 15-hydroxyperoxyarachidonic acid indicates the mechanism to be mediated via the cyclooxygenase. It is, therefore, concluded that the capacity of leukotrienes C4 and D4 to stimulate PGI2 formation might play a key role during acute inflammation at the site of white blood cell accumulation.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0043-5325
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[Vasodilating effect of leukotriene C4 and D4 by stimulation of prostacyclin synthesis].
pubmed:publicationType
Journal Article, English Abstract