| pubmed-article:3517502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0682770 | lld:lifeskim |
| pubmed-article:3517502 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:3517502 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3517502 | pubmed:dateCreated | 1986-6-6 | lld:pubmed |
| pubmed-article:3517502 | pubmed:abstractText | A series of studies was undertaken to correlate the short-term dynamics of LH secretion and depletion-replenishment patterns of estrogen receptors (ER) in hypothalamic and pituitary cytosols of ovariectomized rats. Animals castrated for 2 weeks were administered various test compounds and analyzed at 1, 3, 5, 10 and 15 h post-treatment. A single injection of 10 micrograms 17 beta-estradiol (E2) to ovariectomized rats elicited a rapid depletion of ER in both pituitary and hypothalamus and a dramatic, though delayed, fall in serum LH. ER replenishment occurred in both tissues through 15 h and LH recovered in a similar manner. When cycloheximide was administered along with E2, ER replenishment was completely inhibited in both tissues; serum LH fell and failed to recover. Actinomycin D injected with E2 blocked replenishment in pituitary but not hypothalamus; serum LH recovered in parallel with the hypothalamic ER pattern. 17 alpha-E2 elicited only slight changes in ER and LH was suppressed 10-20% through 15 h. CI-628 caused a near total depletion of pituitary ER with no subsequent replenishment, whereas hypothalamic ER content was virtually unaltered; serum LH was suppressed and later recovered. Orchidectomized rats given 5 micrograms E2 demonstrated a less complete ER depletion in hypothalamus, and an earlier replenishment than that seen in pituitary or hypothalamus of similarly treated ovariectomized females. Serum LH rebounded to 157% of control levels at 15 h. The results indicate that the acute feedback suppression of LH by exposure to estrogens correlates with binding to ER and nuclear translocation. Replenishment and/or retention of cytoplasmic ER in hypothalamus appears to be required for full resumption of LH secretion, following acute suppression. | lld:pubmed |
| pubmed-article:3517502 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3517502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3517502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3517502 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3517502 | pubmed:issn | 0022-4731 | lld:pubmed |
| pubmed-article:3517502 | pubmed:author | pubmed-author:MuldoonT GTG | lld:pubmed |
| pubmed-article:3517502 | pubmed:author | pubmed-author:CidlowskiJ... | lld:pubmed |
| pubmed-article:3517502 | pubmed:author | pubmed-author:EldridgeJ CJC | lld:pubmed |
| pubmed-article:3517502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3517502 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:3517502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3517502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3517502 | pubmed:pagination | 623-8 | lld:pubmed |
| pubmed-article:3517502 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3517502 | pubmed:meshHeading | pubmed-meshheading:3517502-... | lld:pubmed |
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| pubmed-article:3517502 | pubmed:meshHeading | pubmed-meshheading:3517502-... | lld:pubmed |
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| pubmed-article:3517502 | pubmed:meshHeading | pubmed-meshheading:3517502-... | lld:pubmed |
| pubmed-article:3517502 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3517502 | pubmed:articleTitle | Correlation between LH and estrogen receptor turnover in pituitary and hypothalamus of castrate rats following estrogen agonists and antagonists. | lld:pubmed |
| pubmed-article:3517502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3517502 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3517502 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3517502 | lld:pubmed |
