|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1988-3-22
|
|
pubmed:abstractText |
1 Ring segments of bovine left circumflex coronary artery were pre-contracted with 5-hydroxytryptamine or phenylephrine and then exposed to increasing concentrations of calcitonin gene-related peptide (CGRP) and other drugs. 2 CGRP administration resulted in dose-dependent inhibition of induced tone. Maximal relaxation to CGRP was 89 +/- 5% and the concentration required to achieve 50% maximal relaxation (EC50) was 2.11 +/- 1.35 X 10(-9)M. 3 CGRP-induced relaxation was not affected by removal of endothelial cells nor was it significantly altered by incubation of coronary vessels with atropine, propranolol, phentolamine (all 10(-6)M) or indomethacin (10(-5)M). 4 From these data we conclude that CGRP is a potent inhibitor of coronary artery vasomotor tone which appears to act directly on vascular smooth muscle rather than through the release of a secondary mediator. These data support the possibility that CGRP may play a role in non-adrenergic, non-cholinergic regulation of coronary artery tone.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-13576293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2579983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2580718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2861456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2870646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2993964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-2998368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-34490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-3486772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-3567364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-3873022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-3878299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-3917554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-481603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6107863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6137023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6142947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6147756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6254154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6309931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6313250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6346105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6425990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6604878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6609312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6611406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-6806467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3501322-7106182
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
92
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
789-94
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
Calcitonin gene-related peptide (CGRP) is a potent non-endothelium-dependent inhibitor of coronary vasomotor tone.
|
|
pubmed:affiliation |
Respiratory Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
