Linked Life Data

3500574

Source:http://linkedlifedata.com/resource/pubmed/id/3500574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-1-15
pubmed:abstractText
We have derived from spleens of nude mice early B lineage cell lines that are dependent upon factor(s) in supernatants of the WEHI-3B cell line. The cells are phenotypically at the pre-pre-B cell stage of differentiation. These cells are large and have basophilic granules in the cytoplasm. They are negative for cytoplasmic and surface immunoglobulin heavy or light chain, surface B220, surface Thy 1.2 and surface Ia but are positive for cytoplasmic B220. These cells at this early stage of maturation can be induced by mixtures of DC-T cells to express B220 on their surfaces and later to synthesize and ultimately to secrete immunoglobulin. These events are associated with morphologic changes in the cells to a lymphoblastoid appearance. Different pattern of immunoglobulin secretion were induced by DC-T from different tissues. The inductive event appears to occur during cell contact of pre-pre-B cells with the inducing DC-T cell mixture, but it does not appear to require IL-3. These data indicate that DC-T cell mixtures can provide signals for B cell differentiation at pre-pre-B cell stage as well as pre-B and mature B cell stage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
216A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-208
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
A novel pre-B cell precursor: phenotypic characterization and differentiation induction by dendritic cell-T cell mixtures.
pubmed:affiliation
Department of Medicine, University of Alabama, Birmingham.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't