Linked Life Data

3500555

Source:http://linkedlifedata.com/resource/pubmed/id/3500555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-1-14
pubmed:abstractText
Coronary arteriolar vasodilatation may provoke the redistribution of flow to collateral-dependent jeopardized myocardium. To assess the physiologic significance of collateral channels, 80 consecutive postinfarction patients (aged: 58 +/- 8 years) underwent vasodilatation/redistribution thallium-201 tomographic (SPECT) imaging using 0.56 mg dipyridamole/kg body weight. Circumferential profile analysis of redistribution and slow washout in representative left ventricular tomograms provided quantitative evaluation of transient and persistent defects and a separation between a periinfarctional and distant inducible hypoperfusion. Tomographic perfusion data were correlated to subsequent cineangiographic analysis of wall motion and to the extent of collateral circulation between two distinct anatomic perfusion areas, one of which involved the infarct zone. Patients were grouped according to the presence (59%) or absence (41%) of angiographically visible collateral channels to the jeopardized myocardium. In the presence of collaterals, distant reversible defects were larger than in the absence of collaterals (p less than 0.05); the extent of combined periinfarctional and distant redistribution was also larger in collateralized patients (p less than 0.025), whereas the size of the persistent perfusion defect was similar in both groups. In a prospective analysis, the tomographic perfusion pattern of combined periinfarctional and distant ischemia revealed a sensitivity of 85% and a specificity of 78% for the detection of significant collateral circulation in this group of patients. Thus, using the limited collateral flow reserve as a diagnostic tool, vasodilatation/redistribution thallium-201 tomography has some potential for identifying and quantifying collateral-dependent myocardium and may guide diagnostic and therapeutic decision-making.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
612-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Noninvasive identification of collateralized myocardium by 201 thallium tomography in vasodilation and redistribution].
pubmed:affiliation
Division of Nuclear Medicine & Biophysics, UCLA School of Medicine.
pubmed:publicationType
Journal Article, English Abstract