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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1988-1-6
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pubmed:abstractText |
We studied interleukin-1 (IL-1) secretion by rat peritoneal exudate macrophages stimulated with purified toxic shock syndrome toxin-1 (TSST-1). TSST-1 was observed to be a more potent inducer of IL-1 than was endotoxin. The induction of IL-1 secretion by TSST-1 was not blocked by polymyxin B but could be blocked by monoclonal antibodies directed against TSST-1. Synergistic induction of IL-1 was observed when the cells were stimulated with TSST-1 and endotoxin. The sequence of addition was found to be important for the synergistic response. Enhanced IL-1 production was observed only when macrophages were exposed to endotoxin before or simultaneously with TSST-1. Prior exposure of macrophages to TSST-1 had no enhancing effect on endotoxin-induced IL-1 secretion. We conclude that stimulation of the macrophage by endotoxin enhances the responsiveness of the cells to TSST-1 and may thereby play a role in the pathogenesis of toxic shock syndrome.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-149171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3079956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3160540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3486924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3486936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3543677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3733224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3782090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3871225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3871826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3895437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3957424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3957430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-3972449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6119410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6332701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6352497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6369481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6500691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6500702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6500708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6609169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6822419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6833789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-6983710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-7042568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-7432402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3500130-82681
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2865-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3500130-Animals,
pubmed-meshheading:3500130-Antibodies, Monoclonal,
pubmed-meshheading:3500130-Bacterial Toxins,
pubmed-meshheading:3500130-Biological Assay,
pubmed-meshheading:3500130-Drug Synergism,
pubmed-meshheading:3500130-Endotoxins,
pubmed-meshheading:3500130-Enterotoxins,
pubmed-meshheading:3500130-Interleukin-1,
pubmed-meshheading:3500130-Lymphocyte Activation,
pubmed-meshheading:3500130-Macrophages,
pubmed-meshheading:3500130-Rats,
pubmed-meshheading:3500130-Superantigens
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pubmed:year |
1987
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pubmed:articleTitle |
Synergistic induction of interleukin-1 by endotoxin and toxic shock syndrome toxin-1 using rat macrophages.
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pubmed:affiliation |
Department of Anatomy, Medical College of Georgia, Augusta 30912.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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