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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1987-6-9
|
| pubmed:abstractText |
In order to investigate the cause of the anemia concomitant with rheumatoid arthritis (RA), we examined, using the erythroid colony assay of human bone marrow colony-forming units-erythroid (CFU-e) and burst-forming units-erythroid (BFU-e), the effects of the patients' serum and peripheral blood T lymphocytes on the CFU-e-derived colonies. The counts of erythroid colonies of RA patients were markedly lower than those of human control subjects [CFU-e: control 152.9 +/- 30.6 (n = 19), RA 51.1 +/- 13.6 (n = 7), t = 7.66567, p less than 0.01; BFU-e: control 25.2 +/- 5.9 (n = 5), RA 12.6 +/- 2.6 (n = 7), t = 4.574, p less than 0.01]. The serum from two out of seven RA patients slightly inhibited the formation of CFU-e-derived colonies of human control subjects (t = 2.31, 0.05 less than p less than 0.1); however, the serum from the other five RA patients did not significantly inhibit human control erythroid colony formation as compared with human control serum (t = 0.981, 0.3 less than p less than 0.4). On the other hand, peripheral blood T lymphocytes of the patients markedly inhibited the formation of CFU-e-derived colonies of the control subjects as compared with peripheral blood T lymphocytes from human control subjects (t = 4.24, p less than 0.01). The above-mentioned results suggest that the peripheral blood T lymphocytes of RA patients might play a role as one of the causes of the concomitant anemia of RA patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0361-8609
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-11
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3495174-Adult,
pubmed-meshheading:3495174-Anemia,
pubmed-meshheading:3495174-Arthritis, Rheumatoid,
pubmed-meshheading:3495174-Bone Marrow Cells,
pubmed-meshheading:3495174-Cell Count,
pubmed-meshheading:3495174-Cell Division,
pubmed-meshheading:3495174-Colony-Forming Units Assay,
pubmed-meshheading:3495174-Female,
pubmed-meshheading:3495174-Hematopoietic Stem Cells,
pubmed-meshheading:3495174-Humans,
pubmed-meshheading:3495174-Lymphocyte Activation,
pubmed-meshheading:3495174-Male,
pubmed-meshheading:3495174-Middle Aged,
pubmed-meshheading:3495174-T-Lymphocytes
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Immunological aspects of the anemia of rheumatoid arthritis.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|