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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1986-12-16
|
| pubmed:abstractText |
Recent technical and clinical advances in MR of the liver are reviewed with special reference to the role of MR as a primary screening technique for detection of space-occupying lesions, especially metastases. The major current problem in upper abdominal MR imaging is physiologic motions, and this appears to have been effectively solved by newly introduced pulse-sequence and timing-parameter strategies. Short-TR/TE spin-echo sequences with extensive signal averaging and heavy T1-weighting produce images with exceptional anatomic detail and liver-cancer contrast differences. With this sequence superior sensitivity for liver-cancer detection has been shown in quantitative signal-difference to noise comparisons with other pulse sequences and in clinical comparisons with CT. MR discovered 14% more individual metastases and 3% more patients with liver cancer than CT in a blinded comparative study of 142 patients undergoing both exams. MR also showed greater specificity (98%) than CT (91%) in distinguishing patients without liver metastases. Differentiation of hemangioma from metastases was possible with greater than 90% specificity by using heavily T2-weighted sequences. Use of a fast-scan, gradient-recalled echo technique can also produce good-quality, multislice, T1-weighted studies of the liver in 20 sec--a breath-hold. MR contrast agents (such as gadolinium-DTPA and reticuloendothelial-system-specific, superparamagnetic ferrite-iron-oxide particles) offer further promise for enhanced sensitivity for liver-cancer detection. When optimal pulse sequences are employed, MR can now be appropriate as a primary screening method for detecting liver neoplasms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0361-803X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
147
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1103-16
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3490743-Adult,
pubmed-meshheading:3490743-Animals,
pubmed-meshheading:3490743-Contrast Media,
pubmed-meshheading:3490743-Cysts,
pubmed-meshheading:3490743-Diagnosis, Differential,
pubmed-meshheading:3490743-False Negative Reactions,
pubmed-meshheading:3490743-Fatty Liver,
pubmed-meshheading:3490743-Hemangioma,
pubmed-meshheading:3490743-Humans,
pubmed-meshheading:3490743-Liver Diseases,
pubmed-meshheading:3490743-Liver Neoplasms,
pubmed-meshheading:3490743-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3490743-Movement,
pubmed-meshheading:3490743-Physical Phenomena,
pubmed-meshheading:3490743-Physics,
pubmed-meshheading:3490743-Rats,
pubmed-meshheading:3490743-Retrospective Studies,
pubmed-meshheading:3490743-Tomography, X-Ray Computed
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Leo J. Rigler lecture. MR imaging of the liver.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|