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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-8-19
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pubmed:abstractText |
T cell subsets in 10 patients receiving amiodarone were evaluated, and their thyroid function and antithyroid antibodies were assessed. A generalized increase in a recently discovered subset of T cells expressing a complex ganglioside antigen reacting with monoclonal antibody 3G5 was found. Two patients, one with hyperthyroidism and the other with euthyroid Graves' ophthalmopathy, had an additional T cell abnormality--marked increase in Ia-positive T cells (an abnormality typical of patients with spontaneous Graves' disease). In the hyperthyroid patient, the Ia-positive T cells disappeared within three weeks after amiodarone was discontinued. The other patients receiving amiodarone had normal numbers of Ia-positive T cells. These studies indicate that amiodarone alters a major resting T cell subset for almost all patients and is associated with T cells expressing the Ia antigen in selected patients. These T cell abnormalities suggest that amiodarone precipitates organ-specific autoimmunity in susceptible persons.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9343
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3487980-Adult,
pubmed-meshheading:3487980-Aged,
pubmed-meshheading:3487980-Amiodarone,
pubmed-meshheading:3487980-Antibodies, Monoclonal,
pubmed-meshheading:3487980-Autoantibodies,
pubmed-meshheading:3487980-Autoimmune Diseases,
pubmed-meshheading:3487980-Benzofurans,
pubmed-meshheading:3487980-Female,
pubmed-meshheading:3487980-Flow Cytometry,
pubmed-meshheading:3487980-Histocompatibility Antigens Class II,
pubmed-meshheading:3487980-Humans,
pubmed-meshheading:3487980-Male,
pubmed-meshheading:3487980-Microsomes,
pubmed-meshheading:3487980-Middle Aged,
pubmed-meshheading:3487980-T-Lymphocytes,
pubmed-meshheading:3487980-Thyroglobulin,
pubmed-meshheading:3487980-Thyroid Diseases,
pubmed-meshheading:3487980-Thyroid Gland
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pubmed:year |
1986
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pubmed:articleTitle |
Amiodarone therapy and autoimmune thyroid disease. Increase in a new monoclonal antibody-defined T cell subset.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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