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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1986-6-6
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pubmed:abstractText |
The biosynthesis and expression of the tissue-specific class I molecule Qa-2 have been studied in resting and activated T-cell populations. Polyclonal activation of T lymphocytes induces a 3- to 4-fold increase in the biosynthesis of Qa-2 molecules but no increase in cell-surface levels. Analysis of the biosynthetic pathway of the Qa-2 molecule in activated lymphocytes reveals that approximately equal to 70% of the newly synthesized Qa-2 molecules are secreted as soluble molecules. In resting-cell populations, Qa-2 remains entirely cell-associated. This process is unique to the Qa-2 molecule, since other class I molecules (e.g., H-2Kb and H-2Db) synthesized by activated cells remain cell-associated. The possibility that the secreted Qa-2 molecule is the product of a new Qa gene or an alternatively spliced mRNA is considered. These results indicate that the Qa-2 molecules may not just function as a cell-surface recognition structure but also may serve a role as a soluble factor synthesized by activated lymphoid cell populations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-104386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-1059107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-236308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-2580938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-301171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-3160773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-351618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-3838699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-3862106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-3862131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-3871191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-4018029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-565878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-58948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6088985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6143316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6179861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6183577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6280871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6304710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6363595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6435125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6597331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6689056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6788884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6822734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6932473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6942054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-6980125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486423-83153
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2949-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3486423-Animals,
pubmed-meshheading:3486423-Antigens, Surface,
pubmed-meshheading:3486423-H-2 Antigens,
pubmed-meshheading:3486423-Histocompatibility Antigens Class I,
pubmed-meshheading:3486423-Immune Sera,
pubmed-meshheading:3486423-Lymphocyte Activation,
pubmed-meshheading:3486423-Major Histocompatibility Complex,
pubmed-meshheading:3486423-Male,
pubmed-meshheading:3486423-Mice,
pubmed-meshheading:3486423-Mice, Inbred C57BL,
pubmed-meshheading:3486423-Molecular Weight,
pubmed-meshheading:3486423-T-Lymphocytes
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pubmed:year |
1986
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pubmed:articleTitle |
Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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