Linked Life Data

3478392

Source:http://linkedlifedata.com/resource/pubmed/id/3478392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1987-12-11
pubmed:abstractText
This study presents evidence suggesting that multiple binding sites exist for S. mutans JBP (serotype c) in experimental salivary pellicles formed on hydroxyapatite surfaces. Adsorption isotherms were performed using S. mutans JBP cells at concentrations ranging from 1-1000 (x 10(7) streptococci per mL to pellicles prepared from whole clarified saliva and from saliva which had been previously absorbed with JBP cells. The isotherms were analyzed using a one- and a two-site model. Adsorption of S. mutans JBP cells to pellicles formed from untreated saliva was statistically significantly better described by the two-site model, and the two classes of binding sites present had widely different affinities. Also, there were approximately one-third fewer high-affinity sites than low-affinity sites. In contrast, adsorption of S. mutans JBP cells to pellicles formed from JBP-absorbed saliva was better described by the one-site model, and the sites present were of low affinity. Thus, the absorption process appeared to remove or alter specific salivary molecules which comprise the high-affinity binding sites for S. mutans JBP cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1332-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Evidence suggesting multiple binding sites in experimental pellicles for Streptococcus mutans JBP.
pubmed:affiliation
Forsyth Dental Center, Boston, Massachusetts 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't