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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1987-10-19
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pubmed:abstractText |
The synthetic oligonucleotide probes were used for the analysis of N-ras oncogenes detected in human acute leukemias. The mutations of N-ras genes were observed to occur randomly among the subtypes of myeloid leukemias, whereas the N-ras mutations at codon 12 are more likely to occur in lymphoid leukemias than other mutations. The mutations at codon 13 of the N-ras gene were not detected in acute leukemias although they were found in myelodysplastic syndrome that is considered to be a preleukemic state.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
147
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
870-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3477229-Animals,
pubmed-meshheading:3477229-Base Sequence,
pubmed-meshheading:3477229-Cell Line,
pubmed-meshheading:3477229-Cell Transformation, Neoplastic,
pubmed-meshheading:3477229-Gene Expression Regulation,
pubmed-meshheading:3477229-Humans,
pubmed-meshheading:3477229-Leukemia,
pubmed-meshheading:3477229-Leukemia, Lymphoid,
pubmed-meshheading:3477229-Leukemia, Monocytic, Acute,
pubmed-meshheading:3477229-Leukemia, Myeloid, Acute,
pubmed-meshheading:3477229-Mice,
pubmed-meshheading:3477229-Mutation,
pubmed-meshheading:3477229-Nucleic Acid Hybridization,
pubmed-meshheading:3477229-Oligodeoxyribonucleotides,
pubmed-meshheading:3477229-Oncogenes,
pubmed-meshheading:3477229-Transfection
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pubmed:year |
1987
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pubmed:articleTitle |
Activation mechanism of the N-ras oncogene in human leukemias detected by synthetic oligonucleotide probes.
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pubmed:publicationType |
Journal Article
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