Linked Life Data

3475428

Source:http://linkedlifedata.com/resource/pubmed/id/3475428

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-9-16
pubmed:abstractText
Both plasma cortisol and total corticosteroid-binding globulin (CBG) binding capacity were lower in 210 patients with uncomplicated essential hypertension (EH) and their 66 hypertensive first degree relatives, compared with 171 controls. However, both variables were similar in 84 normotensive relatives to those found in control subjects showing extensive variation over the entire control-EH range. The association of reduced plasma cortisol and CBG binding capacity in EH may be closely related to altered steroid metabolism which may be partly explained by an abnormality mimicking a relative deficiency in adrenal 17 alpha- and 11 beta-hydroxylation. One manifestation of this disorder in EH is an increase in the secretion rate and plasma levels of dehydroepiandrosterone sulphate (DHEA-S) which is bound with high-affinity to a low-capacity specific plasma globulin and accounts for most of the digitalis-like activity of human plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S616-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Association of decreased plasma cortisol and corticosteroid-binding globulin binding capacity in patients with essential hypertension and their first degree relatives.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't