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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1987-1-14
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pubmed:abstractText |
The neu oncogene encodes a 185-kDa transmembrane glycoprotein tumor antigen, termed p185. We have recently described a monoclonal antibody reactive with a cell surface domain of the p185 molecule. In vivo treatment with this anti-p185 monoclonal antibody was able to significantly inhibit the tumorigenic growth of neu-transformed NIH 3T3 cells implanted into nude mice. Such treatment had no effect on the tumorigenic growth of Ha-ras-transformed NIH 3T3 cells. Furthermore, anti-p185 antibody treatment was able to inhibit the growth of the rat neuroblastoma cells from which the neu oncogene was initially isolated. These results demonstrate that a monoclonal antibody reactive with the extracellular domain of an oncogene-encoded protein can exert a significant antitumor effect; such antibodies may prove useful in the therapy of certain malignancies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2430175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2860972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2981413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2983097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2992089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2992941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2993906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2995967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2997917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-2999974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-373460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-3883355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-3965572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6086719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6095284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6114284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6121224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6173751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6272120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6285471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6297801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6318979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6351725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6390182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6504162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6577434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-6965328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3466178-80012
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9129-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3466178-Animals,
pubmed-meshheading:3466178-Antibodies, Monoclonal,
pubmed-meshheading:3466178-Antibodies, Neoplasm,
pubmed-meshheading:3466178-Antibody Specificity,
pubmed-meshheading:3466178-Antigens, Neoplasm,
pubmed-meshheading:3466178-Antigens, Surface,
pubmed-meshheading:3466178-Mice,
pubmed-meshheading:3466178-Mice, Nude,
pubmed-meshheading:3466178-Neoplasms, Experimental,
pubmed-meshheading:3466178-Neuroblastoma,
pubmed-meshheading:3466178-Oncogene Proteins, Viral,
pubmed-meshheading:3466178-Rats
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pubmed:year |
1986
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pubmed:articleTitle |
Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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