Linked Life Data

3465365

Source:http://linkedlifedata.com/resource/pubmed/id/3465365

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-9
pubmed:abstractText
Cells from 17 patients with acute myeloid leukaemia (AML) were investigated using the following IgG2a monoclonal antibodies cALL, B1 and Leu 1. Cells from six patients showed binding of cALL, five showed B1 and three showed Leu 1 positivity. Binding of the monoclonal antibodies was shown to be due to Fc binding as it was blocked by prior incubation with aggregated human IgG. Measures such as prior incubation with AB serum or incubation at 37 degrees C were insufficient to block Fc binding in all cases. Fc binding correlated with evidence of monocytic differentiation. Our findings suggest that unless Fc binding is outruled false positive results may be obtained in the investigation of lineage infidelity in AML particularly in monocytic leukaemias.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-46
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Monocytic differentiation in acute myeloid leukaemia: a cause of Fc binding of monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't