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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1986-7-25
|
| pubmed:abstractText |
Four studies of the pharmacokinetics and metabolism of omeprazole are briefly discussed. Two of these were carried out in young healthy subjects and indicated that about 54% of an oral dose is available to the systemic circulation. The distribution of omeprazole after an intravenous dose was consistent with localization of a major fraction of the drug in the extracellular water, with about 25% restricted to the blood. Omeprazole was rapidly cleared and possessed the characteristics of a high clearance drug; insignificant amounts of 14C-omeprazole were excreted by the kidneys, though metabolites were excreted very rapidly. Six different metabolites were reported, the major one being hydroxy-omeprazole. Increasing the intravenous dose of omeprazole from 10 mg to 40 mg had no significant effect on the pharmacokinetic parameters determined. A study in patients with impaired renal function showed that this had little effect on the kinetics of omeprazole, though excretion of metabolites was significantly affected. A study of elderly healthy subjects suggested that the disposition characteristics of omeprazole are affected to some extent by age; further studies are needed to elucidate the clinical implications. Omeprazole has been reported to prolong the half-life of diazepam which may be due to inhibition of the demethylation of diazepam. The interaction of omeprazole with the kinetics of aminopyrine and antipyrine was much less pronounced.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0085-5928
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
99-104
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| pubmed:dateRevised |
2008-2-13
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| pubmed:meshHeading |
pubmed-meshheading:3460172-Administration, Oral,
pubmed-meshheading:3460172-Aged,
pubmed-meshheading:3460172-Aging,
pubmed-meshheading:3460172-Anti-Ulcer Agents,
pubmed-meshheading:3460172-Benzimidazoles,
pubmed-meshheading:3460172-Diazepam,
pubmed-meshheading:3460172-Dose-Response Relationship, Drug,
pubmed-meshheading:3460172-Drug Interactions,
pubmed-meshheading:3460172-Humans,
pubmed-meshheading:3460172-Injections, Intravenous,
pubmed-meshheading:3460172-Kidney Diseases,
pubmed-meshheading:3460172-Kinetics,
pubmed-meshheading:3460172-Omeprazole
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Pharmacokinetics and metabolism of omeprazole in man.
|
| pubmed:publicationType |
Journal Article
|